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sparsentan will minimize the level or outcome of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Keep track of. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and cuts down efficacy connected to these substrates.fosphenytoin will decrease the extent or result of modafinil by impacting hepatic/intestina